This mechanism is most likely through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical response to doxycycline must be monitored intently. Phenytoin, sodium valproate, valproic acid: The outcome of barbiturates to the metabolism of phenytoin appears for being variable. https://peterg543wjw8.liberty-blog.com/profile