Contraindicated. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or lifetime-threatening activities. Contraindicated. "Likely for really serious and/or everyday living-threatening reactions for example acute ergot toxicity characterised by peripheral vasospasm and ischemia on the extremit... https://paxtonqkeye.blogdigy.com/helping-the-others-realize-the-advantages-of-cafergot-discontinued-43299019