Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators in the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have discovered recurrent mutations in genes regulating tumor cell-microenvironment interaction... https://abrahamw086vel2.answerblogs.com/profile