If a mother or father with the proband is known to possess the pathogenic variant recognized in the proband, the risk to your sibs of inheriting the pathogenic variant is fifty%. As a result of diminished penetrance, sibs who inherit the pathogenic variant might or might not develop aHUS (see https://conneroibsj.educationalimpactblog.com/55791527/not-known-facts-about-ahu-s