Abstract Background Inhibition of kinases involved in the DNA damage response sensitizes cells to genotoxic agents by abrogating checkpoint-induced cell cycle arrest. CHK1 and WEE1 act in a pathway upstream of CDK1 to inhibit cell cycle progression in response to damaged DNA. Therapeutic targeting of either CHK1 or WEE1. in combination with chemotherapy. https://www.chiggate.com/turbo-air-m3f72-3-n-78-wide-m3-series-reach-in-freezer-featuring-three-solid-doors-energy-star-online-now/